Now they're at it again.
In conjunction with the new action-comedy blockbuster The Green Hornet, the five fearless investigators of the show place two of the film's action sequences under the microscope.
The film's star, Seth Rogen, appears as a special guest and plays MythBuster for a day.
"I'm a big fan of MythBusters," Rogen said. "We were making a big action movie and it just seemed like the only time we could do something like this. I watch the show all the time and it just seemed cool to see if the stuff in the movie was possible in any way, shape or form."
The programme is based on testing and, as the name suggests, busting myths. Good at science and with a lot of resources available, the MythBusters test whether certain things from movies and urban legends would actually work in real life. Could a ninja catch a flying arrow shot at him, for instance?
Viewers can submit their own myths online at the MythBusters/Discovery Channel website. The show premiered in 2003 (2004 in Hong Kong), and the MythBusters have since put more than 700 myths to the test.
Once they've chosen a myth, the team first re-creates the circumstances. Then they test whether the outcome in the film will occur. At the end of each test, the team gives a verdict: "confirmed", "plausible" or " busted."
For the MythBusters Green Hornet Special, the team tackles two death-defying action sequences from the film: "Explosive Escape" and "Elevator Car Cut".
In "Explosive Escape," the Green Hornet (Rogen) and his trusty sidekick Kato (singer Jay Chou) find themselves buried alive in their car, a 1966 Chrysler Imperial, aka the Black Beauty. The car is refitted with the latest gadgets and weapons.
With no other way of escape, the pair shield themselves under the car seats - which are reinforced with metal - and blast their way to the surface with the car's built-in missiles. In the film, the duo escapes without a scratch. When the myth is tested, dummies are used, just in case they're blown to smithereens.
"Elevator Car Cut" also involves the Black Beauty. During a car chase, the duo drive into a lift, but only the front half of the car gets in. As the lift goes up, the car is cut in half. When the lift reaches the top floor, the pair, sitting in the front half, drives off unharmed. The MythBusters built a custom-made heavy-duty elevator from 3.5 tonnes of steel to see if they can chop the car in half ...
The intrepid MythBusters are Jamie Hyneman, Adam Savage, Tory Belleci, Kari Byron, Grant Imahara, with Jessi Combs as an occasional stand-in. But the real star of the show is Buster, the crash test dummy. Remember, folks, don't try any of their stunts at home.
The MythBusters Green Hornet Special airs on Discovery Channel on Friday at 8pm. The Green Hornet opens February 2.