Between April 23 and 30, the student-led organisation will collect school supplies, including notebooks, binders, art materials and stationery. They will be donated to needy children in Hong Kong, on the mainland and overseas via the Crossroads Foundation.
The campaign is supported by MGPA (Asia) Limited and the Walt Disney Company (Asia).
In a similar week-long campaign last year, Kids4Kids inspired 55 schools and businesses to donate 50,000 used children's books.
"We want to make a difference in the lives of other children who are less fortunate - because we can," said Arielle Watt, one of the charity's advocates who studies at the Hong Kong Academy in Kennedy Town.
"We're delighted to be working with the advocates again to help children help other children," said David Begbie, of the Crossroads Foundation.
"We greatly value Hong Kong's generosity and look forward to getting more children better resources for a better future."
If you want to participate, visit www.kids4kids.org.hk